細胞骨架調控因子PCR芯片 Cytoskeleton & Regulators PCR Array
細胞骨架調控因子PCR芯片 Cytoskeleton & Regulators PCR Array
細胞骨架調控因子PCR芯片 Cytoskeleton & Regulators PCR Array
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| 地區： | 上海 |
| 簡介： | 上海 |
| 提供商： | SABio |
| 服務名稱： | PCR芯片 |
細胞骨架調控因子PCR芯片可用于研究控制細胞內腳手架的生物合成、組織、聚合、解聚作用的84個基因的表達。細胞骨架的組成如肌動蛋白細絲（或微絲），中間絲和微管有許多共同的監管機制但各有獨特的功能。微絲通過如軸突、樹突、絲狀偽足、生長錐、板狀偽足、,微絨毛、偽足和褶邊調節細胞活性、遷移、大小和形狀。肌動蛋白細絲也有助于細胞-細胞及細胞-基質連接、胞質分裂、胞質流動、和肌肉收縮。中間絲似乎不僅與微絲有相同作用，也通過細胞器錨定調控三維細胞結構。微管，有絲分裂紡錘體的核心組成部分，真核生物纖毛和鞭毛的軸絲，控制膜泡運輸和細胞分裂中染色體的分離。芯片上的細胞骨架調節性基因包含鈣調蛋白和鈣調磷酸酶,激酶和磷酸酶和相關ARF和RHO蛋白家族成員以及他們的關鍵調控因子。通過實時定量PCR的方法，研究者即能夠利用該芯片簡單可靠地同時檢測調控細胞骨架動態的基因表達。
Actin Filaments: Interacting Proteins: ACTR2, ACTR3, ARPC1B, ARPC2, ARPC3, ARPC4, ARPC5, CALD1, CDC42EP3, CFL1, CYFIP1, CYFIP2, DIAPH1, DSTN, EZR, FSCN2, GSN, IQGAP2, MACF1, PFN2, RDX, SSH1, SSH2, VASP, WASF1, WASL. Organization & Biogenesis: ARFIP2, ARHGDIB, ARHGEF11, ARPC4, CASK, CDC42, CDC42BPA, ARAP1, CFL1, CRK, DIAPH1, DSTN, EZR, FSCN2, GSN, IQGAP1, LIMK1, LIMK2, NCK1, PFN2, RDX, RHOA, ROCK1, SSH1, SSH2. Polymerization / Depolymerization: ACTR3, ARHGAP6, ARPC1B, ARPC2, ARPC3, ARPC4, ARPC5, CDC42EP2, DSTN, FNBP1L, GSN, NCK1, NCK2, PFN2, PIKFYVE, RAC1, WAS, WASF1, WASL. Cortical Cytoskeleton: ARFIP2, CLASP1, CTTN, DSTN, EZR, LLGL1, MAPRE1. Microtubules: Interacting Proteins: CLASP1CLASP2, CLIP1, CLIP2, MACF1, MAP4, MAPRE1, MAPRE2, MAPT, MID1, RACGAP1, STMN1. Organization & Biogenesis: CLASP1, MAPT, MID1, PHLDB2, STMN1. Polymerization / Depolymerization: CLASP1, CLASP2, MAP4, MAPRE1, MAPRE2, MAPT, STMN1. Spindle Organization & Biogenesis: AURKA, AURKB, CLASP1, CLASP2, CLIP1, MAPRE1, RACGAP1. Cell Projections: Axons & Dendrites: BAIAP2, CDK5, CDK5R1, CYFIP1, CYFIP2, MAPT. Filopodia: BAIAP2, CDC42, CDK5, ARAP1, EZR, MSN, RDX. Growth Cones: CDK5, CDK5R1, MAPT. Lamellipodia: ACTR3, ARFIP2, ARPC5, CDK5, CTTN, CYFIP1, CYFIP2, NCK1, PPP1R12A, PPP1R12B, RAC1, RDX, WASL. Microvilli: EZR, MSN, RDX. Pseudopodia: CDC42, CDC42EP2. Ruffles: ARFIP2, CTTN, CYFIP1, CYFIP2, EZR, RAC1, RDX. Cell Shape, Size, Polarity, Morphogenesis: ARHGEF11, CDC42, CDC42EP2, CDC42EP3, ARAP1, CLASP1, CLASP2, CYFIP1, CYFIP2, EZR, LLGL1, MARK2, MYLK2, SSH1. Cell Motility / Migration: ACTR2, ACTR3, ARFIP2, ARHGDIB, ARHGEF11, ARPC1B, ARPC2, ARPC3, ARPC5, CALD1, CDK5, CDK5R1, ARAP1, DSTN, MSN, NCK1, PAK4, RAC1, ROCK1, WASF1, WASL. Cell Cycle & Cell Division: Mitosis: AURKA, AURKB, CCNA1, CCNB2, CIT, CLASP1, CLASP2, CLIP1, MAPRE1, MAPRE2. Cytokinesis: ARHGEF11, AURKB, AURKC, DSTN, RACGAP1, ROCK1. Cytoskeleton Adaptor Activity: BAIAP2, MSN, NCK1, NCK2, PAK1. Calmodulin / Calcineurin: CALD1, CALM1, CASK, IQGAP1, IQGAP2, MYLK, MYLK2, PPP3CA, PPP3CB. G-Protein Signaling: ARFIP2, ARHGAP6, ARHGDIB, ARHGEF11, CDC42, CDC42EP2, ARAP1, CFL1, CIT, CYFIP1, CYFIP2, DIAPH1, IQGAP1, IQGAP2, LIMK1, LIMK2, MAPK13, RAC1, RACGAP1, RHOA, ROCK1, TIAM1, WAS, WASL. Kinases & Phosphatases: AURKA, AURKB, AURKC, CASK, CDC42BPA, CDK5, CDK5R1, CIT, LIMK1, LIMK2, MAP3K11, MAPK13, MARK2, MYLK, MYLK2, PAK1, PAK4, PPP1R12A, PPP1R12B, PPP3CA, PPP3CB, ROCK1, SSH1, SSH2. |
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