抗真菌反應PCR芯片 Antifungal Response PCR Array
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| 地區： | 上海 |
| 提供商： | SABio |
| 服務名稱： | PCR芯片片 |
抗細菌反應PCR芯片可用于研究參與真菌先天免疫反應的84個關鍵基因的表達。三個不同家族的模式識別受體（TLRs，NLRS，RIG-I樣受體）啟動先天免疫，從而識別常見病原體如真菌等。在真菌感染的初始階段，TLR、NLR和其他PRRs可以識別真菌病原體的特征分子，如?-（1,3）-葡聚糖、甘露聚糖、幾丁質。PAMP受體結合并激活先天免疫反應，啟動下游信號，并誘導炎性細胞因子的表達。對真菌相關的PRRs下游信號通路的了解還不全面，但最近的芯片研究發現了許多真菌感染初始階段的基因。這一芯片包含了參與真菌病原體識別的PRRS，代表其下游的信號轉導通路的基因，以及對白色念珠菌、曲霉菌或隱球菌感染反應有關的基因。通過實時定量PCR的方法，研究者即能夠利用該芯片簡單可靠地同時檢測抗真菌反應相關基因的表達，研究對真菌病原體的先天免疫的機制。 Fungal Pattern Recognition Receptors (PRRs): Beta-Glycan Responsive: CD36, CD5, CLEC7A (Dectin-1), ITGAM, ITGB2, SCARF1, TLR2. Mannose/Chitin Responsive: CD207, CD209, CHIA, CLEC6A (Dectin-2), MRC1, TLR2, TLR4. Other: COLEC12, NLRP3, NPTX1, PTX3, TLR9. Signal Transduction: Dectin-1 Signaling Pathway: BCL10, CARD9, CLEC7A (Dectin-1), MALT1, PLCG2, RAF1, SYK. NF?B Signaling Pathway: BCL10, CARD9, CASP1 (ICE), CASP8 (FLICE), CD40 (TNFRSF5), IKBKB, IL10, IL1B, IRAK1, IRAK4, MALT1, MAP3K7 (TAK1), NFKB1, NFKBIA (IkBa/MAD3), STAT1, TNF. Toll-like receptor (TLR) Signaling Pathway: CASP8 (FLICE), CD14, FOS, IRAK1, IRAK4, ITGB2, JUN, MAP2K4 (JNKK1), MAP3K7 (TAK1), MAPK14 (p38 MAPK), MAPK8 (JNK1), MYD88, NFKB1, TIRAP, TLR2, TLR4, TLR9, TRAF6. Complement Signaling Pathway: C3, C5AR1 (GPR77), ITGAM, ITGB2, LYN, MBL2, SYK. Nod-like Receptor (NLR) Signaling Pathway: CARD9, CASP1 (ICE), NLRP3, PYCARD (TMS1/ASC). Inflammation: C3, CCL2 (MCP-1), CCL20 (MIP-3A), CCL5 (RANTES), CCR1, CD14, CD40 (TNFRSF5), CLEC7A (Dectin-1), CXCL1, CXCL10 (INP10), CXCL11 (I-TAC/IP-9), CXCL2, CXCL9 (MIG), F3, FOS, IL10, IL1A, IL1B, IL2, IL23A, IL6, IL8, ITGB2, LYN, MBL2, MYD88, NFKB1, PTGS2 (COX-2), TIRAP, TLR2, TLR4, TLR9, TNF. Phagocytosis: C3, CD14, CD36, CLEC7A (Dectin-1), COLEC12, FCGR1A, FCN1, MBL2, SFTPD. Genes Responsive to Specific Pathogenic Fungi: Candida albicans: CCL2 (MCP-1), CCL20 (MIP-3A), CCL5 (RANTES), CCR1, CD14, CD209, CD83, CLEC6A (Dectin-2), CLEC7A (Dectin-1), CSF2 (GM-CSF), CSF3 (GCSF), CXCL1, CXCL10 (INP10), CXCL11 (I-TAC/IP-9), CXCL2, CXCL9 (MIG), FCGR1A, FCGR3A, IFNG, IL12B, IL18, IL1A, IL1B, IL1R1, IL23A, IL6, IL8, MYD88, NFKB1, PTGS2 (COX-2), SOCS3, TLR2, TNF. Aspergillus fumigatus: C3, CASP1 (ICE), CASP8 (FLICE), CCL2 (MCP-1), CCL20 (MIP-3A), CCL5 (RANTES), CCR1, CD14, CD40 (TNFRSF5), CD83, CLEC6A (Dectin-2), CLEC7A (Dectin-1), CSF2 (GM-CSF), CSF3 (GCSF), CXCL1, CXCL10 (INP10), CXCL11 (I-TAC/IP-9), CXCL2, CXCL9 (MIG), F2RL1, F3, FCGR1A, FCGR2A, FCN1, IFNG, IL10, IL12A, IL12B, IL18, IL1A, IL1B, IL1R1, IL6, IL8, JUN, MALT1, MAPK14 (p38 MAPK), MBL2, MYD88, NFKBIA (IkBa/MAD3), PTGS2 (COX-2), PTPN6, PTX3, SFTPD, SOCS3, ST3GAL5, STAT1, SYK, TLR2, TLR4, TLR9, TNF. Cryptococcus neoformans: C3, CD5, CCL2 (MCP-1), CD40 (TNFRSF5), SOCS3. |
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