胰島素信號通路PCR芯片 Insulin Signaling Pathway PCR Array
胰島素信號通路PCR芯片 Insulin Signaling Pathway PCR Array
胰島素信號通路PCR芯片 Insulin Signaling Pathway PCR Array
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| 地區： | 上海 |
| 簡介： | 上海 |
| 提供商： | SABio |
| 服務名稱： | PCR芯片 |
胰島素信號通路PCR芯片可檢測與胰島素反應有關的84個基因。芯片包含了與胰島素受體有關的基因和胰島素信號通路的靶基因，碳水化合物、脂類、蛋白代謝有關的基因和相關的生物學反應有關的基因也包括在內。此外，芯片還包含PI3K和MAPK信號通路的成員。通過實時定量PCR的方法，研究者即能夠利用該芯片簡單可靠地同時檢測胰島素反應相關的基因表達。 Insulin Receptor-Associated Proteins: Insulin and Receptors: INS, INSL3, IRS1, IRS2, IRS4, SORBS1. Insulin-like Growth Factors and Receptors: IGF1R, IGF2, IGFBP1. SH3/SH2 Adaptor Protein: CBL, GAB1, GRB2, IRS4, NCK1. Other Genes Associated with Insulin Receptor Proteins: CAP1, DOK1, DOK2, DOK3, FRS2, FRS3, INSR, PDPK1, PPP1CA, PTPN1, PTPRF, SHC1. PI-3 Kinase Pathway: Components: AKT1, AKT2, AKT3, EIF2B1, EIF4EBP1, MTOR, GSK3A, GSK3B, PDPK1, PIK3CA, PIK3R1, PIK3R2, PRKCG, PRKCI, PRKCZ. Target Genes: BCL2L1, DUSP14, G6PC, HK2, IGFBP1, PCK2, SERPINE1, SLC2A4, SREBF1, UCP1, VEGFA MAPK Pathway: Components: ARAF, BRAF, EIF2B1, GRB2, HRAS, MAP2K1, MAPK1, RAF1, RPS6KA1, RRAS, RRAS2, SHC1, SOS1. Target genes: ANG, BCL2L1, ERCC1, FOS, LDLR, NOS2, UCP1. Primary Target Genes for Insulin Signaling: CEBPA, CEBPB, FOS, JUN, LEP, PRL. Secondary Effector Target Genes for Insulin Signaling: NPY, PCK2, SLC2A1, SLC2A4, TG. Target genes for PPARg: ACOX1, ADRB3, AEBP1, CAP1, CEBPA, CEBPB, PCK2, PPARG, RETN. Target genes for SREBP1: ACACA, FBP1, G6PC, GCK, PCK2, PKM2. Carbohydrate Metabolism: Glucose Metabolism: FBP1, G6PC, GCK, HK2, INS, IRS2, PCK2, PKM2, SLC2A1, SLC2A4, SORBS1. Glycogen Metabolism: G6PC, GSK3B, PPP1CA. Other Genes Related to Carbohydrate Metabolism: ADRB3, GPD1, INSR. Lipid Metabolism: Cholesterol Metabolism:LDLR, SREBF1. Fatty Acid Metabolism: ACACA, ACOX1, FASN. Lipid Transport: LDLR, SORBS1. Other Lipid Metabolism Genes: ARAF, BRAF, INS, LEP, PPARG, PRKCG, PRKCI, PRKCZ, RAF1, SHC1. Protein Metabolism: Protein Amino Acid Dephosphorylation: DUSP14, PPP1CA, PTPN1, PTPRF. Protein Amino Acid Phosphorylation: AKT1, AKT2, AKT3, ARAF, BRAF, GSK3A, GSK3B, IGF1R, INSL3, INSR, MAP2K1, MAPK1, PDPK1, PRKCG, PRKCI, PRKCZ, RAF1, RPS6KA1. Protein Biosynthesis: ANG, EIF2B1, EIF4EBP1, LDLR, PPP1CA. Protein Transport: PRKCI, RRAS2. Other Protein Metabolism Genes: AEBP1, CBL, DOK1, DOK2, FRS2, GAB1, IRS1, NOS2, SORBS1, VEGFA. Transcription Factors and Regulators: DNA-dependent Regulation of Transcription: CEBPA, CEBPB, FOS, JUN, PPARG, SREBF1. RNA Polymerase II Transcription Factor Activity: CEBPA, FOS, JUN, SREBF1. Transcription Factors: AEBP1, CBL, CEBPA, CEBPB, JUN, PPARG, SREBF1. Cell Growth and Differentiation: Cell Cycle: MTOR, HK2, HRAS, IGF1R, IGF2, KRAS, MAPK1, VEGFA. Cell Proliferation: GAB1, IGF1R, IGF2, IRS2, NCK1, NPY, PRL, RAF1, SHC1, VEGFA. Growth Factors and Receptors: GAB1, GRB2, IGF1R, IGF2, IGFBP1, INSR, SHC1, VEGFA. Cell differentiation: NOS2, PPARG |
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