地區: | 上海 |
簡介: | 上海 |
提供商: | SABio |
服務名稱: | PCR芯片 |
細胞壞死PCR芯片可用于研究與細胞壞死相關的84個關鍵基因的表達。細胞壞死(也被稱為壞死性凋亡,編程性壞死,脹亡或三型細胞死亡)最近被證明是一個受特定調控的細胞過程。通過絲氨酸/酪氨酸激酶RIPK1活化的死亡受體包括(FAS,TNRSF1A以及TNFRSF10A)。RIPK1 和RIPK3以及活化的PARP1相互作用導致一些線粒體相關的效應沒,比如:活性氧種類(ROS)的增加,細胞溶質鈣的增加以及ATP的缺失。這張芯片包括程序性壞死相關的基因,死亡受體相信號,ROS的產生或線粒體活性。細胞壞死和調亡可以激活相同的死亡受體,因此,芯片上還包括細胞死亡程序的下游效應分子,從而可以發現細胞壞死的新的分子機制。利用實時定量PCR,研究者可以方便并且可信地對與細胞程序性壞死相關的基因進行同時檢測。 Necrosis: Regulation of Necrosis: FAS (TNFRSF6), FASLG (TNFSF6), RIPK1, SLC25A4, TNF. Required for TNF-Induced Necrosis: ATP6V1G2, BMF, C1orf159, CCDC103, COMMD4, CYLD, DEFB1, DENND4A, DPYSL4, EIF5B, FOXI1, GALNT5, GRB2, HSPBAP1, JPH3, KCNIP1, MAG, OR10J3, PARP2, PVR, RAB25, S100A7A, SPATA2, SYCP2, TMEM57, TXNL4B. Other Necrosis Genes: CD40 (TNFRSF5), FADD, MGEA5, RIPK1, RIPK3, PARP1 (ADPRT1), PPIA, SP1, TMEM123. Potential Necrosis Genes: RIPK1 Interactors: FUS, NFKB1, RIPK2, RIPK3. RIPK3 Interactors: GLUD1, GLUL, PYGL, RIPK1. PARP1 Interactors: CAPN1, CAPN2, CAPN3, CAPN5, CAPN6, CAPN7, CAPNS1, PPID. Death Domain Receptors: FAS (TNFRSF6), TNFRSF1A (TNFR1), TNFRSF10A (TRAIL-R). Death Receptor Signaling: BID, BIRC3 (c-IAP1), CASP8AP2, CYLD, EDA2R, FADD, FAF1, FEM1B, IKBKG, LRDD (PIDD), MADD, MYD88, NGF, NGFR, NGFRAP1, PARP1 (ADPRT1), RIPK1, TNFRSF14, TNFRSF17, TNFRSF1B, TNFRSF25 (DR3), TNFRSF4 (OX40), TNFRSF8, TNFSF15, TRADD, TRAF2. Apoptosis: Pro-Apoptosis: AIFM1 (PDCD8), BAX, BID, BMF, BNIP3L, CASP8AP2, FADD, FAF1, FAS (TNFRSF6), FASLG (TNFSF6), FEM1B, IKBKG, LRDD (PIDD), MADD, NGFR, NGFRAP1, RIPK1, RIPK2, RIPK3, TNF, TNFRSF10A (TRAIL-R), TNFRSF25 (DR3), TNFRSF8, TNFSF10 (TRAIL), TRADD, TRAF2. Anti-Apoptosis: BIRC3 (c-IAP1), BNIP3L, FAS (TNFRSF6), MYD88, NFKB1, NGF, NGFR, RIPK1, RIPK2, TNF, TNFRSF1A, TNFRSF1B, TNFRSF4 (OX40), TRAF2. Required for TNF-Induced Apoptosis: ATP6V1G2, CYLD, SPATA2, SYCP2. Reactive Oxygen Species (ROS) Activity: AIFM1 (PDCD8), CYBB, GLUD1, NOX1, NOX4. Mitochondrial Genes: AIFM1 (PDCD8), BAX, BID, BNIP3L, CYBB, GLUD1, GLUL, PPID, RIPK1, SLC25A4 |