神經營養因子以及受體PCR芯片可用于研究與神經元過程相關的84個關鍵基因的表達。該芯片包含神經營養信號分子包括神經營養因子和神經肽,以及它們的受體。參與神經系統正常功能的基因如:神經細胞生長,分化,神經再生和存活相關的基因也包含在這張芯片里。參與神經信號的細胞因子和受體,神經沖動傳導的基因,神經營養因子和轉錄因子調控的細胞凋亡相關基因和和神經系統下游通路的活性的調節因子。利用實時定量PCR,研究者可以方便并且可信地對與神經系統相關的基因進行同時檢測。 Neurotrophins and Receptors: ADCYAP1R1, ARTN, BDNF, CD40 (TNFRSF5), CNTF, CNTFR, CRHBP, CRHR1, CRHR2, FRS2, FRS3, FUS, GDNF, GFRA1, GFRA2, GFRA3, GMFB, GMFG, MAGED1, MT3, NF1, NGF, NGFR, NGFRAP1, NR1I2, NRG1, NRG2, NTF3, NTF4, NTRK1, NTRK2, PSPN, PTGER2, TFG, TRO, VGF. Neuropeptides and Receptors: Neuropeptide Hormone: CRH, NPFF, NPY, PNOC, UCN. Bombesin Receptors: GRPR. Cholecystokinin Receptors: CCKAR. Galanin Receptors: GALR1, GALR2. Neuropeptide Y Receptors: NPY1R, NPY2R, PPYR1. Neurotensin Receptors: NTSR1. Tachykinin and Receptors: TACR1. Other Neuropeptides and Receptors: NPFFR2 (GPR74), HCRT, MC2R. Neurogenesis: Central Nervous System Development: PSPN. Peripheral Nervous System Development: GFRA3. Negative Regulation of Neurogenesis: MT3. Other Neurogenesis Related Genes: ARTN, BDNF, CBLN1, CNTF, CNTFR, FGF2, GDNF, MEF2C, NELL1, NGFR, NRG1, NTF3, NTRK1, NTRK2, STAT3, TFG. Transmission of Nerve Impulse: CBLN1, CNTF, CRH, GALR1, GALR2, HCRT, NPFF, NPY, NTSR1, PNOC. Cell Growth and Differentiation: Growth Factors and Receptors: ARTN, BDNF, CNTF, FGF2, FGF9, FGFR1, FRS2, FRS3, GDNF, GMFB, GMFG, IL10, IL1B, IL6, LIF, NGF, NRG1, NRG2, NRG4, NTF3, NTF4, PSPN, TGFA, TGFB1, VGF. Cell Cycle: BAX, BCL2, FGF2, FGF9, IL1B, MYC, NF1, STAT1, TGFA, TGFB1, TP53. Cell Proliferation: BCL2, FGF2, FGF9, GRPR, IL10, IL1B, IL6, IL6R, LIF, MT3, MYC, NF1, NPY, TGFA, TGFB1, TP53. Cell Differentiation: FGF9, IL10, NRG1, TP53. Cytokines and Receptors: CNTFR, CX3CR1, CXCR4, IL10, IL10RA, IL1B, IL1R1, IL6, IL6R, IL6ST, LIF, LIFR. Apoptosis: Anti-Apoptosis: BCL2, FAS (TNFRSF6), GDNF, IL10, NRG2, NTF3, TGFB1. Caspase Activation: STAT1, TP53. Induction of Apoptosis: BAX, FAS (TNFRSF6), TP53. Other Genes Related to Apoptosis: CD40 (TNFRSF5), HSPB1, IL1B, NGFR, NGFRAP1. Immune Response: Acute-Phase Response: IL6, STAT3. Humoral Immune Response: BCL2, CD40 (TNFRSF5), IL10, IL1B, IL6. Inflammatory Response: CD40 (TNFRSF5), FOS, IL10, IL1B, IL1R1, TACR1. Other Immune Response Genes: FAS (TNFRSF6), CRH, CRHR1, CX3CR1, IL6R, IL6ST, LIF. Transcription Factors and Regulators: RNA Polymerase II Transcription Factors: FOS, MEF2C. Transcription Coactivators: MEF2C, NR1I2. Transcription Factors: MEF2C, MYC, NR1I2, STAT1, STAT2, STAT3, STAT4, TP53. |