細(xì)胞骨架調(diào)控因子PCR芯片 Cytoskeleton & Regulators PCR Array
細(xì)胞骨架調(diào)控因子PCR芯片 Cytoskeleton & Regulators PCR Array
細(xì)胞骨架調(diào)控因子PCR芯片 Cytoskeleton & Regulators PCR Array
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| 地區(qū)： | 上海 |
| 簡介： | 上海 |
| 提供商： | SABio |
| 服務(wù)名稱： | PCR芯片 |
細(xì)胞骨架調(diào)控因子PCR芯片可用于研究控制細(xì)胞內(nèi)腳手架的生物合成、組織、聚合、解聚作用的84個基因的表達(dá)。細(xì)胞骨架的組成如肌動蛋白細(xì)絲（或微絲），中間絲和微管有許多共同的監(jiān)管機(jī)制但各有獨(dú)特的功能。微絲通過如軸突、樹突、絲狀偽足、生長錐、板狀偽足、,微絨毛、偽足和褶邊調(diào)節(jié)細(xì)胞活性、遷移、大小和形狀。肌動蛋白細(xì)絲也有助于細(xì)胞-細(xì)胞及細(xì)胞-基質(zhì)連接、胞質(zhì)分裂、胞質(zhì)流動、和肌肉收縮。中間絲似乎不僅與微絲有相同作用，也通過細(xì)胞器錨定調(diào)控三維細(xì)胞結(jié)構(gòu)。微管，有絲分裂紡錘體的核心組成部分，真核生物纖毛和鞭毛的軸絲，控制膜泡運(yùn)輸和細(xì)胞分裂中染色體的分離。芯片上的細(xì)胞骨架調(diào)節(jié)性基因包含鈣調(diào)蛋白和鈣調(diào)磷酸酶,激酶和磷酸酶和相關(guān)ARF和RHO蛋白家族成員以及他們的關(guān)鍵調(diào)控因子。通過實時定量PCR的方法，研究者即能夠利用該芯片簡單可靠地同時檢測調(diào)控細(xì)胞骨架動態(tài)的基因表達(dá)。
Actin Filaments: Interacting Proteins: ACTR2, ACTR3, ARPC1B, ARPC2, ARPC3, ARPC4, ARPC5, CALD1, CDC42EP3, CFL1, CYFIP1, CYFIP2, DIAPH1, DSTN, EZR, FSCN2, GSN, IQGAP2, MACF1, PFN2, RDX, SSH1, SSH2, VASP, WASF1, WASL. Organization & Biogenesis: ARFIP2, ARHGDIB, ARHGEF11, ARPC4, CASK, CDC42, CDC42BPA, ARAP1, CFL1, CRK, DIAPH1, DSTN, EZR, FSCN2, GSN, IQGAP1, LIMK1, LIMK2, NCK1, PFN2, RDX, RHOA, ROCK1, SSH1, SSH2. Polymerization / Depolymerization: ACTR3, ARHGAP6, ARPC1B, ARPC2, ARPC3, ARPC4, ARPC5, CDC42EP2, DSTN, FNBP1L, GSN, NCK1, NCK2, PFN2, PIKFYVE, RAC1, WAS, WASF1, WASL. Cortical Cytoskeleton: ARFIP2, CLASP1, CTTN, DSTN, EZR, LLGL1, MAPRE1. Microtubules: Interacting Proteins: CLASP1CLASP2, CLIP1, CLIP2, MACF1, MAP4, MAPRE1, MAPRE2, MAPT, MID1, RACGAP1, STMN1. Organization & Biogenesis: CLASP1, MAPT, MID1, PHLDB2, STMN1. Polymerization / Depolymerization: CLASP1, CLASP2, MAP4, MAPRE1, MAPRE2, MAPT, STMN1. Spindle Organization & Biogenesis: AURKA, AURKB, CLASP1, CLASP2, CLIP1, MAPRE1, RACGAP1. Cell Projections: Axons & Dendrites: BAIAP2, CDK5, CDK5R1, CYFIP1, CYFIP2, MAPT. Filopodia: BAIAP2, CDC42, CDK5, ARAP1, EZR, MSN, RDX. Growth Cones: CDK5, CDK5R1, MAPT. Lamellipodia: ACTR3, ARFIP2, ARPC5, CDK5, CTTN, CYFIP1, CYFIP2, NCK1, PPP1R12A, PPP1R12B, RAC1, RDX, WASL. Microvilli: EZR, MSN, RDX. Pseudopodia: CDC42, CDC42EP2. Ruffles: ARFIP2, CTTN, CYFIP1, CYFIP2, EZR, RAC1, RDX. Cell Shape, Size, Polarity, Morphogenesis: ARHGEF11, CDC42, CDC42EP2, CDC42EP3, ARAP1, CLASP1, CLASP2, CYFIP1, CYFIP2, EZR, LLGL1, MARK2, MYLK2, SSH1. Cell Motility / Migration: ACTR2, ACTR3, ARFIP2, ARHGDIB, ARHGEF11, ARPC1B, ARPC2, ARPC3, ARPC5, CALD1, CDK5, CDK5R1, ARAP1, DSTN, MSN, NCK1, PAK4, RAC1, ROCK1, WASF1, WASL. Cell Cycle & Cell Division: Mitosis: AURKA, AURKB, CCNA1, CCNB2, CIT, CLASP1, CLASP2, CLIP1, MAPRE1, MAPRE2. Cytokinesis: ARHGEF11, AURKB, AURKC, DSTN, RACGAP1, ROCK1. Cytoskeleton Adaptor Activity: BAIAP2, MSN, NCK1, NCK2, PAK1. Calmodulin / Calcineurin: CALD1, CALM1, CASK, IQGAP1, IQGAP2, MYLK, MYLK2, PPP3CA, PPP3CB. G-Protein Signaling: ARFIP2, ARHGAP6, ARHGDIB, ARHGEF11, CDC42, CDC42EP2, ARAP1, CFL1, CIT, CYFIP1, CYFIP2, DIAPH1, IQGAP1, IQGAP2, LIMK1, LIMK2, MAPK13, RAC1, RACGAP1, RHOA, ROCK1, TIAM1, WAS, WASL. Kinases & Phosphatases: AURKA, AURKB, AURKC, CASK, CDC42BPA, CDK5, CDK5R1, CIT, LIMK1, LIMK2, MAP3K11, MAPK13, MARK2, MYLK, MYLK2, PAK1, PAK4, PPP1R12A, PPP1R12B, PPP3CA, PPP3CB, ROCK1, SSH1, SSH2. |
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