胃癌qBiomarker拷貝數(shù)PCR芯片 Gastric Cancer qBiomarker Copy Number PCR Arrays
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胃癌qBiomarker拷貝數(shù)PCR芯片 Gastric Cancer qBiomarker Copy Number PCR Arrays
胃癌qBiomarker拷貝數(shù)PCR芯片 Gastric Cancer qBiomarker Copy Number PCR Arrays
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| 簡介： | Gastric Cancer qBiomarker Copy Number PCR Arrays 胃癌qBiomarker拷貝數(shù)PCR芯片 |
| 提供商： | SAbiosciences |
| 服務(wù)名稱： | 胃癌qBiomarker拷貝數(shù)PCR芯片 |
| 地區(qū)： | 美國 |
“英拜為您實驗加速” 技術(shù)服務(wù)網(wǎng)址：http://hj5388.com/ 服務(wù)熱線：400-696-6643、 18019265738 郵箱：daihp@yingbio.com 、 huizhang1228@foxmail.com Gastric Cancer qBiomarker Copy Number PCR Arrays 胃癌qBiomarker拷貝數(shù)PCR芯片
he Human Gastric Cancer qBiomarker Copy Number PCR Array profiles the copy number of 23 genes reported to undergo frequent genomic alterations in human stomach tumor DNA. Gastric cancer, or stomach cancer, originates in any part of the stomach, but can spread to other organs such as the esophagus, liver, lungs, and lymph nodes. Improving the very poor prognosis of this disease requires identifying early molecular markers, and progress has been made in identifying acquired copy number alterations (CNA) in key oncogenic pathways. During oncogenesis, large percentages of gastric tumors acquire insertions and deletions in genes that regulate epithelial cell and fibroblast proliferation and differentiation, as well as signaling pathways such as WNT. Genes were chosen from the most frequently amplified or deleted genes relevant to oncogenic pathways and gastric cancer biology based on the primary literature and public databases. This array may serve as a useful tool to help classify gastric cancer samples by genotype and help verify gastric cancer phenotypic biomarkers. The array analyzes each gene in each sample in quadruplicate and includes a stable multi-copy reference assay for accurate copy number determination via appropriate DNA input normalization. The simplicity of the product format and operating procedure allow routine and reliable copy number profiling in any research laboratory with access to a real-time PCR instrument.The qBiomarker Copy Number PCR Arrays are intended for molecular biology applications. This product is not intended for the diagnosis, prevention, or treatment of a disease.96-well Plate, 384-well (4 × 96) Plate, and 100-well Disc formats are available 胃癌qBiomarker拷貝數(shù)PCR芯片用于研究已報道的與人類胃癌有關(guān)且發(fā)生頻繁突變的23個基因的拷貝數(shù)。許多基因的拷貝數(shù)變異都會導(dǎo)致先天性異常胃癌起源于胃的任何部分,但可以擴散到其他器官如食道、肝、肺和淋巴結(jié)。改善這種疾病很差的預(yù)后,需要識別早期的分子標記,以及在關(guān)鍵致癌途徑中識別獲得拷貝數(shù)突變(CNA)的進程。在腫瘤形成過程中,大比例的胃腫瘤捕獲插入和刪除的基因，這些基因調(diào)節(jié)上皮細胞和成纖維細胞增殖和分化，以及WNT等信號通 基因選擇自主要文獻和公共數(shù)據(jù)庫中致癌途徑和胃癌生物學(xué)基礎(chǔ)上擴增或缺失的相關(guān)基因。這個芯片可助于胃癌樣本的基因型分類并驗證胃癌癥表型生物標記。這個芯片可以使每個基因在每個樣本中有四個重復(fù)，同時包含一個穩(wěn)定的多拷貝參考實驗，通過適當?shù)腄NA插入標準化精確檢測拷貝數(shù)。簡單的產(chǎn)品模式和操作程序讓任何一個具備實時定量PCR儀的實驗室都可進行常規(guī)可靠的拷貝數(shù)檢測。 qBiomarker拷貝數(shù)PCR芯片用于分子生物學(xué)應(yīng)用。本產(chǎn)品不用于疾病的診斷、預(yù)防和治療。 提供96孔板，384 -(4×96)板，和100 孔。 Cell Cycle: FBXW7. Channels & Transporters: ATP7B. Chaperone Activity: BAG2. Cytoskeleton: CTNNB1, FAM84B, IQGAP1. ECM & Cell Adhesion: ADAM23, CD44, CEACAM6. Epigenetics: MED1. G-Protein Signaling: DOCK8, IQGAP1. Growth Factors: SFRP1, WNT2. Hedgehog Signaling: MTSS1, RAB23. Metabolic Enzymes: AOAH, GLO1, MTAP. Receptor Tyrosine Kinases: ERBB3. Transcription Factors: FOXO1, ZFHX3. Ubiquitin Ligase: FBXW7. Others: LRRC4C, PPP1R1B |
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