心臟毒性PCR芯片可用于研究由藥物或化合物誘導而發生心臟損傷的84個關鍵基因的表達。毒性反應是藥物上市的檢測指標之一，其中就包括心臟毒性反應的檢測。出于安全考慮，在過去40年，約有10%的藥品因為對心血管有影響而撤出臨床市場。傳統的形態學研究昂貴又耗時，且很難分辨是否為藥物或化合物引發的心臟毒性反應。這一芯片包含了多個模型中由于藥物或化合物引起的心臟損傷的生物標志物基因，既減少了實驗周期和成本，也能在研究最初階段就發現和剔除會引起心臟毒性反應的藥物。通過實時定量PCR的方法，研究者即能夠利用該芯片簡單可靠地同時檢測心臟毒性相關基因的表達。
Up-Regulated: Muscle Contraction: KBTBD10. Angiogenesis: IL6, PLAU, SERPINE1, TGFB2. Signal Transduction: ABRA, ADRA2A, CCR1, CREM, IL6, RND1, SIK1, TGFB2, TIAM1. Cell Cycle: BCAT1, FOSL1, HSPA2, SIK1, TGFB2. Development: BTG2, CREM, EGR1, FHL1, HSPA2, IL6, RND1, SIK1, SPP1, TGFB2, TIAM1, TIMP1, UCP1, VCAN. Metabolism (Regulation & Mechanism): ABRA, ADRA2A, BTG2, CH25H, CREM, EGR1, FOSL1, IL6, PDK4, PLA2G4A, PUM2, RBM3, SIK1, TCF4, TGFB2, TIMP1. Migration / Motility: ABHD2, CCL7, CCR1, FOSL1, IL6, PLAU, PPBP, PVR, TGFB2. Other: CD14, CFD, CKM, FCGR2B, GPM6A, HAMP, KBTBD5, MT1F, PLUNC, REG3G, TUBB6, UCK2. Down-Regulated: Muscle Contraction: ACTA1, GJA1, KCNJ12, RPS6KB1. Angiogenesis: COL15A1, POSTN, VEGFA. Signal Transduction: AIFM1, DUSP8, GJA1, IGFBP5, ITPR2, RPS6KB1, S1PR2, THRAP3. Cell Cycle: CSNK2A2, MCM6, PSMA2, PSMD7, TXNIP. Development: ACTA1, COL15A1, COL3A1, GJA1, IGFBP5, PLN, RPS6KB1, SOX4, TXNIP. Metabolism (Regulation & Mechanism): ASH1L, ATP5J, DUSP8, IGFBP5, MCM6, NFIB, PPP1R14C, PRKAB2, S1PR2, SOX4, THRAP3, TXNIP, ZNF148, ZNF23. Migration / Motility: IGFBP5, NEXN, RPS6KB1. Other: AK3, BGN, BSN, HSPH1, IFT20, PKN2, SLC4A3, UBA5, UBXN2A, VIM, WIPI1. |
