地區(qū): | 上海 |
簡介: | 上海 |
提供商: | SABio |
服務(wù)名稱: | PCR芯片 |
克羅恩病PCR芯片可用于研究在腸道炎癥(IBD)中差異表達的84個基因的表達。克羅恩病與潰瘍性結(jié)腸炎(UC)都是常見的腸道炎癥。腸炎的主要癥狀包括腹痛、嘔吐、腹瀉等,持續(xù)性的炎癥會導(dǎo)致體重減輕,引發(fā)結(jié)腸或直腸癌,甚至因此切除器官。在炎癥發(fā)生和惡化過程中,作為細胞外重構(gòu)酶的炎癥細胞因子,調(diào)節(jié)免疫反應(yīng)的T細胞均發(fā)揮了重要作用,是研究各種腸道炎癥的生物標志物。早期的表達譜芯片研究發(fā)現(xiàn)了與克羅恩氏病和UC先相關(guān)的基因,這些基因均已收錄在這一芯片上。通過實時定量PCR的方法,研究者即能夠利用該芯片簡單可靠地同時檢測腸道炎癥相關(guān)基因的表達。 Apoptosis: CASP1 (ICE), CCL2 (MCP-1), EGR3, IL1B, IL2RA (CD25), IL6, ITGB2, LCN2 (NGAL), SOD2, TNF. Inflammation: C3, CCL11 (Eotaxin), CCL2 (MCP-1), CCL20 (MIP-3A), CCL25 (TECK), CCL5 (RANTES), CCR1, CCR2, CCR5, CX3CL1, CXCL1, CXCL10 (INP10), CXCL11 (I-TAC/IP9), CXCL2, CXCL3, CXCL9 (MIG), CXCR1 (IL8RA), FPR1, IL13, IL17A, IL1B, IL2RA (CD25), IL23A, IL5, IL6, IL8, ITGB2, LTB, LYZ, S100A8, S100A9, SAA1, SELE, STAT3, TNF. Immunity: Humoral: CCL2 (MCP-1), IL6, DEFA5, DEFA6, LYZ. Innate: C3, C4BPB, CASP1, CD55, CR2, IL1RN, IRF5, ISG15 (G1P2), LCN2 (NGAL), NOD2, NOS2 (iNOS), SAA1, TYK2. Adaptive: CCL11 (Eotaxin), CCR2, CCR5, CCR9, CXCR3, HLA-DQA1, HLA-DRA, HLA-DRB1, IFNG, IL13, IL17A, IL2RA (CD25), IL5, IL6, IRF5, STAT1. Adhesion & Remodeling: CCL2 (MCP-1), CCR1, CCL11 (Eotaxin), CSTA, CX3CR1, CXCL12 (SDF1), CXCR3, ITGB2, MMP1, MMP10, MMP3, MMP7, PECAM1, SELE, SELL (LECAM1), TIMP1, VWF. Unfolded Protein Response: HSP90B1 (TRA1), HSPA5 (GRP78), UBD. Digestive Secreted Proteins: GCG, MUC1, REG1A, REG1B, TFF1 (pS2). Metabolism: ALDOB, PCK1, TDO2. Other Genes: ABCB1 (MDR1), ATG16L1, CHI3L1, EDN3, NR3C2. |