地區: | 上海 |
簡介: | 上海 |
提供商: | SABio |
服務名稱: | PCR芯片 |
原癌基因和抑癌基因PCR芯片可用于研究促進癌變的84個核心基因的表達。此芯片所含的基因,有致癌或抑癌或兩者兼有,取決于腫瘤的類型也來源于已知的或相匹配的正常組織的基因表達差異。利用腫瘤樣本來分析這些基因的表達,可能與它們的生物學表型或臨床結果如臨床分期、治療方案的選擇、轉移、復發和生存率等等有關。結果也可以深入了解腫瘤發生和腫瘤病理學發生的分子機制和生物學途徑,包括解除管制的細胞凋亡、細胞周期、細胞黏附、DNA損傷和修復以及信號轉導。通過實時定量PCR的方法,研究者即能夠利用該芯片簡單可靠地同時檢測腫瘤發生相關基因的表達。 Oncogenes: BAX, BCL2L1, CASP8, CDK4, ELK1, ETS1, HGF, JAK2, JUNB, JUND, KIT, KITLG, MCL1, MET, MOS, MYB, NFKBIA, NRAS, PIK3CA, PML, PRKCA, RAF1, RARA, REL, ROS1, RUNX1, SRC, STAT3, ZHX2. Tumor Suppressor Genes: ATM, BRCA1, BRCA2, CDH1, CDKN2B, CDKN3, E2F1, FHIT, FOXD3, HIC1, IGF2R, MEN1, MGMT, MLH1, NF1, NF2, RASSF1, RUNX3, S100A4, SERPINB5, SMAD4, STK11, TP73, TSC1, VHL, WT1, WWOX, XRCC1. Both Oncogenic & Tumor Suppressor Properties: BCR, EGF, ERBB2, ESR1, FOS, HRAS, JUN, KRAS, MDM2, MYC, MYCN, NFKB1, PIK3C2A, RB1, RET, SH3PXD2A, TGFB1, TNF, TP53. Transcription Factors: ABL1, BRCA1, BRCA2, CDKN2A, CTNNB1, E2F1, ELK1, ESR1, ETS1, FOS, FOXD3, HIC1, JUN, JUNB, JUND, MDM2, MEN1, MYB, MYC, MYCN, NF1, NFKB1, PML, RARA, RB1, REL, RUNX1, RUNX3, SMAD4, STAT3, TGFB1, TNF, TP53, TP73, TSC1, VHL, WT1, ZHX2. Epithelial-to-Mesenchymal Transition: BRCA2, CDKN2B, CTNNB1, ERBB2, HGF, JAK2, KIT, MCL1, NF1, RUNX3, S100A4, SMAD4, TGFB1, VHL. Angiogenesis: AKT1, CTNNB1, EGF, ERBB2, NF1, PML, RUNX1, TGFB1. Apoptosis: BAX, BCL2, BCL2L1, BRCA1, CASP8, E2F1, MCL1, MGMT, TNF, VHL. Cell Adhesion: APC, CDH1, CDKN2A, CTNNB1, KITLG, NF1, NF2, TGFB1. Cell Cycle: ATM, BRCA1, BRCA2, CCND1, CDK4, CDKN1A, CDKN2A, CDKN2B, CDKN3, E2F1, HGF, MEN1, STK11, TP53. |